Fentanyl seizure data, collected by U.S. Customs and Border Protection (CBP), quantifies interdiction efforts against this synthetic opioid, which is 50 times more potent than heroin. Seizures are measured in both pounds of pure fentanyl and pill form equivalents, with data categorized by point of entry, transportation method, and concealment techniques. The majority (approximately 90%) of seizures occur at land ports of entry, particularly along the Southwest border. CBP employs multiple detection methods: canine units, non-intrusive inspection technology (NII), and laboratory analysis. Seizure patterns reveal sophisticated trafficking networks, with Mexican cartels being primary suppliers using Chinese-sourced precursor chemicals. The data tracks various fentanyl analogs, cutting agents, and distribution patterns. Seizure quantities correlate with overdose death rates, street-level purity analysis, and price data, providing crucial intelligence for law enforcement strategy, public health responses, and international cooperation efforts. This metric has shown exponential growth, with seizures increasing over 400% since 2019, reflecting both improved detection and increased trafficking.